Evaluating the hepatitis C landscape in Canada: a CanHepC special topic series
CanHepC is partnering with the Canadian Liver Journal to publish a special topic series of articles documenting the hepatitis C problem in Canada.
Last updated: January 3, 2019
The series, guest edited by Dr Naglaa Shoukry (CanHepC Principal-Investigator and Director), Dr Jordan Feld (CanHepC Co-Principal Investigator) and Dr Jason Grebely (CanHepC Investigator), aims to provide an up-to-date evaluation of the hepatitis C landscape in Canada while looking at the remaining key research questions and challenges to address. CanHepC member’s, including some of Canada’s top hepatitis C experts have been commissioned to write these articles which will be spread out over several issues of the Canadian Liver Journal (CanLivJ).
The series consists of mostly review articles and a couple of original research articles on a range of topics specific to the Canadian context providing updated estimates and projections of the epidemiology of the hepatitis C infection in Canada and modelling of the future burden of disease, addressing HCV in key populations such as Indigenous, newcomers, people who use drugs and pediatric populations, challenges regarding treatment delivery and the cascade of care including optimal testing strategies, remaining clinical challenges and the role of DAA treatment in reversing liver damage and immune dysfunction, and the role of community in achieving HCV elimination. Finally, a research framework for a national action plan based on the WHO framework will also be proposed.
With this series, we hope to give an accurate portrait of the hepatitis C situation in Canada and provide the background framework to inform the establishment of a national hepatitis action plan to reach the World Health Organization hepatitis elimination targets by 2030.
All article are open access and are added to this page as they become available.
Editorial
- Hepatitis C: A Canadian perspective (Naglaa H Shoukry, Jordan J Feld, Jason Grebely)
Original research
- Diagnosis and treatment of hepatitis C virus infection: a tool for engagement with people who inject drugs in Vancouver’s Downtown Eastside (Arshia Alimohammadi, Julie Holeksa, Robyn Parsons, Rossita Yung, Neilofar Amiri, David Truong, Brian Conway)
- In the eyes of Indigenous people in Canada: exposing the underlying colonial etiology of hepatitis C and the imperative for trauma-informed care (Sadeem T Fayed, Alexandra King, Malcolm King, Chris Macklin, Jessica Demeria, Norma Rabbitskin, Bonnie Healy, Stewart Gonzales)
- Patterns of practice and barriers to care for hepatitis C in the direct-acting antiviral (DAA) era: A national survey of Canadian infectious diseases physicians (Justin Chan, Jim Young, Joseph Cox, Roy Nitulescu, Marina B Klein)
Review articles
- The role of prevention strategies in achieving HCV elimination in Canada: what are the remaining challenges? (Stine Bordier Høj, Nanor Minoyan, Andreea Adelina Artenie, Jason Grebely, Julie Bruneau)
- Addressing hepatitis C in the foreign-born population: A key to hepatitis C virus elimination in Canada (Christina Greenaway, Iuliia Makarenko, Fozia Tanveer, Naveed Z Janjua)
- Can we afford not to screen and treat hepatitis C virus infection in Canada? (William WL Wong, Alex Haines, Hooman Farhang Zangneh, Hemant Shah)
- Remaining clinical issues in hepatitis C treatment (Alexander Wong, Cynthia Tsien, Sarah Mansour, Curtis Cooper)
- Reversing immune dysfunction and liver damage after direct-acting antiviral treatment for hepatitis C (Sabrina Mazouz, Maude Boisvert, Naglaa H Shoukry, Daniel Lamarre)
- Progress toward approval of an HCV vaccine (John LM Law, Mike Logan, Amir Landi, D Lorne Tyrrell, Michael Houghton)
- Contextualizing Canada’s hepatitis C virus epidemic (Mel Krajden, Darrel Cook, Naveed Zafar Janjua)
- Hepatitis C models of care: approaches to elimination (Mia J Biondi, Jordan J Feld)
- Hepatitis C virus (HCV) care in Canadian correctional facilities: Where are we and where do we need to be? (Nadine Kronfli, Jane A Buxton, Lindsay Jennings, Fiona Kouyoumdjian, Alexander Wong)
- Hepatitis C virus infection in mothers and children (Emma Greenaway, Mia J Biondi, Jordan J Feld, Simon C Ling)
